![]() ![]() The study showed significant and sustainable improvements of skin hydration, elasticity, and roughness. ![]() In this former non-controlled pilot trial, which was conducted in 16 healthy women, ELASTEN ® was orally applied for 3 months. Due to the loss of collagen, the skin becomes increasingly thinner and drier.Ī previous pilot study demonstrated that the oral intake of special bioactive collagen peptides, also tested in the present trial, induce beneficial effects on human skin structure and function. The elasticity is then diminished, and lines and wrinkles emerge. Factors such as sunlight, smoking, environmental pollution, alcohol abuse, and nutrient deficiency can accelerate this process. Collagen formation is diminished in mature skin and the biomatrix of the skin begins to collapse when the collagen scaffold loses its strength and stability. As such, rejuvenation of the biomatrix can be effectively improved only through a supply of sufficient nutrients via the blood stream. ![]() Collagen fibers are synthesized primarily by the fibroblasts in the deeper layers of the skin. The collagen content of young and healthy skin has been demonstrated to exceed 75%. The unique (high coverage-) collagen complex (ELASTEN ®) tested here contains short chain oligopeptides composed of 5 to 8, 9 to 15, and 16 to 26 amino acids and have a high coverage with amino acids sequences found in human skin collagen proteins.Įxternal and internal factors drive the physiological process of skin aging associated with a decline in collagen formation. Typical collagen hydrolysates are composed of peptides of different lengths and, depending on the collagen source, are characterized by a special amino acid composition. After ingestion, they are further metabolized to bioactive di- and tri-peptides in the gastrointestinal tract, which are then released into the blood stream and accumulated in the skin to form the collagen biomatrix. These oligopeptides are obtained by enzymatic hydrolysis of natural collagen. Studies have shown that age-dependent reduction in collagen synthesis can be reversed by oral administration of specific bioactive collagen peptides. These building blocks combine to form collagen fibrils of enormous strength and tensile force. Three chains wind around each other forming a collagen triple helix. The structure of collagen is reminiscent of a rope. ![]() The extracellular matrix retains water and supports a smooth, firm, and strong skin. Many different factors exacerbate the aging process of the skin, including intrinsic ageing, irradiation, consumption of a non-balanced diet, and stress-related deficiencies in micronutrients, leading to an age-dependent collagen loss in the skin.Ĭollagen, the most abundant component of the extracellular matrix, is the decisive protein that determines skin physiology, by maintaining the skin structure and enabling its numerous functions to take place. Healthy skin provides an active interface between the internal and external environments of the body and enables permanent adaptation and acclimatization of an organism during its lifetime. The measured effects were fully consistent with the subjective assessments of the study participants. These positive effects were substantially retained during the follow-up. The differences between the verum group and the placebo group were statistically significant for all test parameters. The test product significantly improved skin hydration, elasticity, roughness, and density. The verum group was followed for an additional four weeks (without intake of the test product) to evaluate the sustainability of the changes induced by the intake of the test product. A skin assessment was carried out and based on objective validated methods, including corneometry (skin hydration), cutometry (elasticity), the use of silicon skin replicas with optical 3D phase-shift rapid in-vivo measurements (PRIMOS) (roughness), and skin sonography (density). They received either the food supplement ( n = 36) or a placebo ( n = 36) for twelve weeks. This controlled interventional trial was performed on 72 healthy women aged 35 years or older. Drinking ampoules provides a blend of 2.5 g of collagen peptides, acerola fruit extract, vitamin C, zinc, biotin, and a native vitamin E complex. The purpose of this randomized, placebo-controlled, blind study was to investigate the effects of the drinkable nutraceutical ELASTEN ® (QUIRIS Healthcare, Gütersloh, Germany) on skin aging and skin health. ![]()
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