The treatment protocol for control and eradication of Coenurosis cerebralis was performed at the herd level, which was associated with a successful therapeutic response. The results showed diffuse meningoencephalitis with infiltration of multinucleated inflammatory cells, perivascular inflammation, cerebrovascular thrombosis, cochlear necrosis, and destruction of a large part of brain tissue due to parasitic migration suggesting an acute form of the disease. For further studies, radiographs were taken from the animals’ heads at standard views, and then, two of the dead animals were autopsied and histopathologically examined for brain tissue. Clinical examination showed no significant changes in vital signs and further hematobiochemical investigation revealed eosinophilia and hyperproteinemia in affected sheep. Five Lori sheep from a flock with neurological symptoms, seizures, and fatalities were referred to the Veterinary Teaching Hospital of Lorestan University with a history of no antiparasitic treatment for the past 6 months. Coenurosis is a parasitic disease in livestock animals caused by Taenia multiceps, whose adult parasite lives in the intestine of the Canidae and ruminants and the most important symptoms are nervous system involvement.
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